nucleoside monophosphate kinase 3d models
39 3d models found related to nucleoside monophosphate kinase.thingiverse
This is one part of dimer of RAF protein kinase, and with its whole structure, it contains a dimer of the RAF kinase domain in the center and two copies of MEK bound on the outside. As we know, RAF has important roles in cell metabolism and if it...
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Ribbon model of the tyrosine kinase portion of the insulin receptor.
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Pyruvate Kinase protein in two pieces to be glued together.
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Phosphoglycerate Kinase protein in two pieces to be glued together.
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Imatinib (STI-571) is a tyrosine kinase inhibitor used for chronic myelogenous leukaemia (CML). CML causes undesirable activation of the Abelson tyrosine kinase (Abl). The activity of Abl in pateinets with CML is uncontrolled. Using an inhibitor,...
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... Although Tyr628 was phosphorylated by the insulin receptor, its catalytic turnover was poor, resulting in kinase inhibition. ...Our studies indicate that the KRLB region functions to limit tyrosine phosphorylation of IRS2.(PubMed abstract)
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... Although Tyr628 was phosphorylated by the insulin receptor, its catalytic turnover was poor, resulting in kinase inhibition. ...Our studies indicate that the KRLB region functions to limit tyrosine phosphorylation of IRS2.(PubMed abstract)
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EGFR is a transmembrane tyrosine kinase receptor that upon activation with EGF on the extracellular domain, facilitate cell proliferation, survival, motility and differentiation. EGFR forms a homodimer on both the extracellular and cytoplasmic...
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... binding to STI-571. The binding of STI-571 is the adoption by the kinase of an inactive conformation, in which a centrally located “activation loop” is not phosphorylated. ... PDB ID: 1FPU , DOI: 10.1126/science.289.5486.1938 & PMID: 12154025
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This thing was made with Tinkercad. ...Edit it online https://www.tinkercad.com/things/cYLJ75Vx29G
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Epidermal Growth factor receptros(EGFT) are transmembrane receptor tyrosine kinase that signal critical for cell proliferation. Mutations upon EGFR kinase are one of the most common cause of clustered cell lung cancer, where 40% of the mutation are...
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By 470400962 and 470449499 Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase Thomas Schindler,1 William Bornmann,3 Patricia Pellicena,4 W. ...Todd Miller,4 Bayard Clarkson,3 John Kuriyan1,2*
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The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase protein that dimerises in response to growth factor binding, resulting the activation of the cytoplasmic tyrosine kinase domain. This initiates intracellular...
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... Although Tyr628 was phosphorylated by the insulin receptor, its catalytic turnover was poor, resulting in kinase inhibition. ...Our studies indicate that the KRLB region functions to limit tyrosine phosphorylation of IRS2.(PubMed abstract)
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The human epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase involved in the transduction of signals controlled epidermal cell proliferation, differentiation and motility. This virtual tour explores the EGFR kinase domain in...
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![Alt text](http://www.hhmi.org/sites/default/files/styles/biointeractive_summary/public/Biointeractive/Images/Gleevec-Inhibits-Cancer-Causing-Kinase-BCR-ABL.jpg?itok=GdYE7o1Z )Gleevec Inhibits Cancer-Causing Kinase BCR-ABL: How the drug Gleevec...
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... CDK6 and CDK9. However, despite this specificity, abemaciclib also inhibits other cellular protein kinases, leading to gastrointestinal toxicity. ...This is explored in the above diagram, which depicts the interactions between abemaciclib and CDK6.
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mTORC1 is a key regulator of cellular growth and proliferation by driving the phosphorylation of S6K1 that acts downstream of the PI3 kinase pathway. When NR1, a selective inhibitor, binds to the switch II domain of Rheb, the activation of mTORC1 is...
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... 13, pp. 4808-4817. Structural Information: Schindler, T, Bornmann, W, Pellicena, P, Miller, WT, Clarkson, B & Kuriyan, J 2000, ‘Structural mechanism for STI-571 inhibition of abelson tyrosine kinase’, Science, vol. 289, no. 5486, pp. ...1938-1942.
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Abeaciclib is one of the lastest generation (third generation) inhibitors for cyclin-dependent kinase 6. Unlike the first and second genereation drugs it is highly specific to CDK4/6 and has relative high potency. This model illustrated the contact...
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EGFR is a receptor tyrosine kinase that plays a critical role in the signal transduction pathway underpinning cell proliferation & differentiation. Its tyrosine kinase domain (TKD) functions to bind and facilitate phosphate transfer from ATP &...
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These include the key residues within the Hinge loop that undergo hydrogen bonding to the ligand, the location of the G-loop whose conformational change allows tighter binding, and the residues that contribute to Dinaciclib’s specificity for the CDK...
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Cyclin Dependent Kinase 6 (CDK6) is an enzyme that plays an important role in the cell division cycle: as a result, mutations to CDK6 may result in the development of tumours and cancers. It is therefore important to find drugs that inhibit the...
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It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, a vascular endothelial growth factor receptor antagonist and an angiogenesis modulating agent. It is a member of indazoles, an aminopyrimidine and a sulfonamide. It is a conjugate...
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SH3 (SRC Homology 3) domains are a type of protein structure found widely in nature:http://en.wikipedia.org/wiki/SH3_domain This SH3 domain is from c-Src specific tyrosine kinase. Model based on the Protein Data Bank entry...
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mTORC1 is part of the Ser/Thr kinase family and is a master regulator of cellular growth and metabolism. It interacts with a GTP-binding protein, Rheb, which contains a Switch 2 region. This region binds to the mTOR catalytic domain and activates it....
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Lyn is a tyrosine kinase necessary in the B-cell activation pathway. It phosphorylates ITAMs on IgA and IgB in order to further transduce the signal of the B cell receptor binding an antigen. Function results from “Amplification of B Cell Antigen...
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NO는 구아닐레이트 사이클레이즈(guanylate cyclase)라는 효소의 활성을 증가시켜 cGMP(cyclic guanosine monophosphate)의 생성을 증가시킨다. cGMP가 평활근을 이완시키고, 음경해면체로 혈류의 유입을 증가시켜 발기가 일어난다. 발기부전치료제는 남성 성기의 혈관 평활근을 이완시켜 혈관확장을 일으킨다. 음경해면체의 동맥이 확장되면 장기로 들어가는 혈액량이 증가되어 남성 성기에서는 발기부전이 개선된다. 불안하면...
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NO는 구아닐레이트 사이클레이즈(guanylate cyclase)라는 효소의 활성을 증가시켜 cGMP(cyclic guanosine monophosphate)의 생성을 증가시킨다. cGMP가 평활근을 이완시키고, 음경해면체로 혈류의 유입을 증가시켜 발기가 일어난다. 발기부전치료제는 남성 성기의 혈관 평활근을 이완시켜 혈관확장을 일으킨다. 음경해면체의 동맥이 확장되면 장기로 들어가는 혈액량이 증가되어 남성 성기에서는 발기부전이 개선된다. 불안하면...
grabcad
NO는 구아닐레이트 사이클레이즈(guanylate cyclase)라는 효소의 활성을 증가시켜 cGMP(cyclic guanosine monophosphate)의 생성을 증가시킨다. cGMP가 평활근을 이완시키고, 음경해면체로 혈류의 유입을 증가시켜 발기가 일어난다. 발기부전치료제는 남성 성기의 혈관 평활근을 이완시켜 혈관확장을 일으킨다. 음경해면체의 동맥이 확장되면 장기로 들어가는 혈액량이 증가되어 남성 성기에서는 발기부전이 개선된다. 불안하면...