DNA repair enzyme MutS from E. coli

prusaprinters

<p>The machinery that copies DNA makes an error approximately every 10 million bases. That may not seem like much if you are a bacterium that only has 5 million bases in its genome, but if you replicate once per hour, then on average half of your descendants have a mutation, and this number rapidly approaches 100% as you near the end of the day.</p> <p>It stands to reason, then, that E coli needs something more than just proofreading polymerases to keep its DNA from mutating, and that is where the mismatch repair protein MutS fits in.</p> <p>MutS clamps on to the mismatched base pairing and recruits other proteins that perform the repair.</p> <p>Read more here <a href="http://en.wikipedia.org/wiki/MutS-1">http://en.wikipedia.org/wiki/MutS-1</a></p> <h3>Instructions</h3> <p>I got this model from PDB structure 3zlj.</p> <p>Printed using KISSlicer, 0.15 layer height and 0.5mm extrusion width, 15% infill and with the support flow rate decreased to 75% by an external script.</p> Category: Biology