EGFR in complex with inhibitor AFN941

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The human epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase involved in the transduction of signals controlled epidermal cell proliferation, differentiation and motility. This virtual tour explores the EGFR kinase domain in complex with inhibitor AFN941 (PDB code 2ITW), and how interactions may be disturbed by other point mutations. Presented by 470391833 and 470419218. Context: Yun, C-H, Boggon, TJ, Li, Y, Woo, MS, Greulich, H, Meyerson, M & Eck, MJ 2007, ‘Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity’, Cancer Cell, vol. 11, no. 3, pp. 217-227.