Hydrogel Hand Bone Scaffolds

thingiverse

Over 900,000 patients undergo a bone-related surgery each year that may require a bone implant. The immune system is very good at fighting foreign bodies, so implant rejection is a frequent concern. Epibone is a Brooklyn-based biotech startup aiming to grow personalized bone implants. Using stem cells from a patient’s fatty tissue and mico-CT scans of their bone defect, Epibone can create an implant that will be recognized as the patient’s own tissue. Chris Venter and I from Autodesk’s Bio/Nano Research Team collaborated with Epibone to print bone scaffolds for cell growth. The design and construction of these scaffolds are exceptional examples of Autodesk technologies working in concert to create an innovative produce. The files included in this Thing are hand bones printed the same way Epibone’s implants would be, meaning they have the potential to be used for autologous bone growth. This hand model was used to display our technology at Autodesk University 2015 in Las Vegas. Included in Miscellaneous notes are more details about the bone modeling and printing requirements. Print Settings Printer: Autodesk Ember Rafts: No Supports: No Resolution: 50 um Infill: Trabecular lattice How I Designed This This folder contains: Scaled, trabecularized bone finger STL files ready to print with MeshMixer supports. Find all my hand bones, trabecularized with mesh mixer supports ready to be printed, in the Hand bone STL files were originally downloaded from Thingiverse here: http://www.thingiverse.com/thing:15342 There are 27 finger bones total. Finger bones label 1 to 5 corresponding to the thumb bones to the pinky bones, respectfully. Note that 1MP starts at the first finger, not the thumb, and 4MP ends at the pinky bone. All bones and naming conventions: DP = Distal phalange. 1DP, 2DP, 3DP, 4DP, 5DP. MP = Manual intermediate phalange. 1MP, 2MP, 3MP, 4MP. PP = Manual proximal phalange. 1PP, 2PP, 3PP, 4PP, 5PP. MC = Metacarpal. 1MC, 2MC, 3MC, 4MC, 5MC. TRP = Trapezium TRZ = Trapezoid SCP = Scaphoid CAP = Capitate LUN = Lunate TRQ = Triquetral PIS = Pisiform HAM = Hamate All the bone files in this thingiverse download are the same size, which is anatomically incorrect. I rescaled them in Fusion360 based approximate sizes from http://eskeletons.org/boneviewer/nid/12537/region/hands/bone/Articulated%20hand. The hand, from wrist to the tip of the third finger, is 8", a somewhat standard adult hand size. Some of the bones in the thingiverse link are labeled incorrectly. There are also two bones missing (1MC and 4PP). I added fake bones by rescaling copies of other bones. After rescaling the models, the bones were populated with a trabecular lattice using the software tool WithinMedical: http://www.autodesk.com/products/within/features/within-medical/all/list-view. The lattice settings used are: lattice target beam size = 0.3 mm lattice target pore size = 0.45 mm I used MeshMixer (http://www.meshmixer.com/) to generate support structures so the models could be printed on an Autodesk Ember Printer (https://ember.autodesk.com/). I printed the bone scaffolds in a photocurable PEGDA resin created by Chris Venter on Autodesk's Ember DLP printer. The Ember uses a web-based printer environment called Spark (http://www.emberprinter.com/). Simply upload the models I provided here to www.emberprinter.com after creating a free user account. The Spark print settings for our PEGDA resin are: Layer thickness = 50 microns First layer exposure time = 11 seconds Burn in layers = 4 Burn in layer exposure time = 11 seconds Model Exposure time = 6.5 seconds Website I used to piece together finger bones:http://eskeletons.org/boneviewer/nid/12537/region/hands/bone/Articulated%20hand Rescaling and positioning handbones in Fusion360 Trabecular lattice printed in PEGDA resin on the Autodesk Ember DLP printer Epibone's bone and bioreactor Trabecularized TMJ bone in WithinMedical Project poster for Autodesk University 2015.