Insulin receptor kinase / IRS2 KRLB peptide

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PBD: https://www.rcsb.org/structure/3bu3 IUPHAR: http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=321 Insulin receptor substrates 1 and 2 (IRS1 and -2) are crucial adaptor proteins in mediating the metabolic and mitogenic effects of insulin and insulin-like growth factor 1. In the structure, this segment of IRS2 is bound in the kinase active site with Tyr628 positioned for phosphorylation. Although Tyr628 was phosphorylated by the insulin receptor, its catalytic turnover was poor, resulting in kinase inhibition. Our studies indicate that the KRLB region functions to limit tyrosine phosphorylation of IRS2.(PubMed abstract)