Lyn-1

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Lyn is a tyrosine kinase necessary in the B-cell activation pathway. It phosphorylates ITAMs on IgA and IgB in order to further transduce the signal of the B cell receptor binding an antigen. Function results from “Amplification of B Cell Antigen Receptor Signaling by a Syk/ITAM Positive Feedback Loop” from Rolli et. al. (2002). The structural data were accessed using the Protein Data Bank (http://www.rcsb.org/) (1W1F, 4TZI, 3A4O) and the ePMV pluggin in Cinema 4D. This 3D model is a component of larger interactive virtual reality project (being) developed by Ben Magod ‘17, Betsy Henson ‘17, Stephen Himmelberg ‘17, and Laurel Romano ’17 as part of the Fall 2016 BIOL 385 (Molecular Mechanics of Life) class at Washington and Lee University with the help of the IQ Center.