N8 Neuraminidase + Oseltamivir Structure

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BCHM3X82 Assignment by ELISEUS FENG & WILLIAM ZHOU The protein N8 Neuraminidase cleaves the glycosidic bonds of sialic acid to enable the virus to be released from the cell and propagate throughout the body. Sialic acid is a key component of a bacteria’s cell wall and occurs in high concentrations forming synapses between neurons and the nervous system. The annotations portray key binding sites between the drug and the active site and changes in protein conformation as this occurs. The drug oseltamivir is an antiviral used to treat influenza A and B. Recent mutations of influenza have developed resistance, the annotations also present potential binding sites for future drugs to exploit.