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The Human Factor in Space Exploration is a crucial aspect that has been overlooked by many scientists and engineers. The Human Body is capable of adapting to extreme environments, but it also has its limitations. For instance, long-term exposure to Microgravity can cause severe health problems, including Muscle Atrophy and Bone Loss. Astronauts who spend extended periods in Space are also at risk of experiencing Vision Impairment and Hearing Loss due to the unique conditions on the International Space Station. Additionally, the lack of Gravity affects the way Fluids move through the Body, leading to swelling in the Face and Legs. Despite these challenges, Scientists and Engineers continue to push the boundaries of what is possible with Human Spaceflight. By studying the effects of Microgravity on the Human Body, they can develop new technologies and strategies to mitigate its negative impacts. However, there are also opportunities for Humans to contribute positively to Space Exploration. For example, Astronauts have been instrumental in conducting research and gathering data that has greatly expanded our understanding of the Universe. Their unique perspective as Humans in Space has also provided valuable insights into the importance of preserving the Environment on Earth. As we continue to venture further into Space, it is essential that we prioritize the Health and Safety of Human Astronauts. By doing so, we can ensure that they remain healthy and productive throughout their time in Space, ultimately contributing to the success of our Space Exploration endeavors.