Structure of bromodomain and its interactions

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A bromodomain is a protein domain that recognizes acerylated lysine residues on a histone in post-translational modifications. In certain species, hyperacetylation is noticed during spermiogenesis, just before chromatin compaction. Bromodomains usually contain two asymmetrical bromodomains, but the 3D model that is being represented is of a single bromodomain (BD1), which is represented in all white, that is bound to an acetylated histone protein – H4K5acK8ac peptide. The yellow compound corresponds to the histone protein bound to BD1. Also highlited on BD1 are specific side chains that are important in the binding to the histone protein. References: Morinière, J., Rousseaux, S., Steuerwald, U. et al. Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Nature 461, 664–668 (2009). https://doi.org/10.1038/nature08397