The binding of PBP3 & Meropenem
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Irreversible inhibition of PBP3 by Meropenem (a β-lactam antibiotic). Meropenem binds to PBP3 inhibiting the production of peptidoglycan resulting in bacterial cell wall death. Han, S., Zaniewski, R. P., Marr, E. S., Lacey, B. M., Tomaras, A. P., Evdokimov, A., . . . Shanmugasundaram, V. (2010). Structural basis for effectiveness of siderophoreconjugated monocarbams against clinically relevant. Proceedings of the National Academy of Sciences of the United States of America, 22002-22007.
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